Sequence Alignment and BLAST

Learn how to compare biological sequences, uncover evolutionary relationships and explore what sequence alignment can reveal across genomics, proteomics and bioinformatics.

5 hours

None

Intermediate

Course information

This course provides a practical introduction to sequence alignment techniques, with a focus on BLAST and multiple sequence alignment. It will help you understand how biological sequences can be compared and analysed to identify similarities, functional elements and evolutionary relationships, building a useful foundation for work in genomics, proteomics and bioinformatics.

Designed for people beginning their journey in bioinformatics, the course combines short self-paced learning sessions with video tutorials, reading materials and small practical challenges.

By the end, you will have a clearer understanding of how sequence alignment works, where it can be applied, and how it can support biological sequence analysis in research and professional contexts.

Learning objectives

  • Source fasta sequences in NCBI
  • Run BLAST alignments using nucleotides and amino acids
  • Run multiple sequence alignments
  • Translate a nucleotide sequence to obtain the amino acid version
  • Visualise an alignment